New research has identified a potential link between the use of certain cholesterol-lowering medications during pregnancy and an increased risk of autism spectrum disorder (ASD) in children. The study, published in the journal Nature Medicine, focuses on drugs that inhibit an enzyme involved in cholesterol synthesis.
The investigation analyzed health data from over 3 million mother-child pairs. It found that children born to mothers who were prescribed these specific cholesterol synthesis inhibitors, such as some statins, during pregnancy had a modestly higher likelihood of being diagnosed with autism compared to those whose mothers did not take them. The association was stronger with multiple prescriptions.
Researchers emphasize the findings show a correlation, not direct causation, and stress that untreated high cholesterol also poses significant health risks. The study calls for heightened scrutiny of drug safety during pregnancy and more cautious, individualized prescribing, urging further research to understand the biological mechanisms involved.
Medical experts advise that pregnant individuals or those planning pregnancy should not stop any prescribed medication without first consulting their healthcare provider to weigh the benefits and risks.
