Lilly's Retevmo Adjuvant NSCLC Study at ASCO 2026

Phase 3 LIBRETTO-432 trial of Retevmo as adjuvant therapy in RET fusion-positive NSCLC to be presented at ASCO 2026 plenary.

Lilly's Retevmo Adjuvant NSCLC Study at ASCO 2026

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Eli Lilly and Company announced that data from the Phase 3 LIBRETTO-432 study evaluating Retevmo (selpercatinib) as adjuvant therapy in patients with RET fusion-positive non-small cell lung cancer (NSCLC) will be featured in the Plenary Session and the ASCO press program at the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting, taking place June 5-9, 2026, in Chicago.

The LIBRETTO-432 trial is a randomized, double-blind, placebo-controlled study assessing the efficacy and safety of Retevmo in patients with stage IB-IIIA RET fusion-positive NSCLC who have completed definitive therapy. The primary endpoint is event-free survival (EFS). This marks the first Phase 3 study of a RET inhibitor in the adjuvant setting for this patient population.

In addition, Lilly will present data from an investigator-initiated study of Verzenio (abemaciclib) in patients with advanced breast cancer, along with other oncology pipeline assets across multiple tumor types and treatment modalities. The full ASCO 2026 abstract titles will be released on May 13, 2026, at 5:00 PM ET.

Lilly's oncology portfolio includes approved medicines such as Verzenio (abemaciclib), Retevmo (selpercatinib), and Cyramza (ramucirumab), as well as investigational agents. The company continues to explore new indications and combinations to address unmet medical needs in cancer care.

❓ Frequently Asked Questions

What is the LIBRETTO-432 study?

It is a Phase 3 trial evaluating Retevmo (selpercatinib) as adjuvant therapy in patients with RET fusion-positive non-small cell lung cancer (NSCLC) after definitive treatment.

When and where is the 2026 ASCO Annual Meeting?

The meeting takes place June 5-9, 2026, in Chicago, Illinois.

What is the primary endpoint of LIBRETTO-432?

The primary endpoint is event-free survival (EFS).

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