At the International Society of Gynecological Endocrinology (ISGE) Congress 2026 in Rome, Italy, researchers presented findings linking early menopause to an increased risk of cognitive decline and dementia. The study, published in EMJ Reproductive Health, highlights the need for early intervention in women experiencing menopause before age 40.
Lead author Alena Sofieva from EMJ, London, UK, noted that the loss of estrogen during early menopause may accelerate brain aging. The research reviewed data from multiple cohort studies, showing that women with premature ovarian insufficiency (POI) have a 30% higher risk of developing dementia later in life.
Experts recommend that women with early menopause consider hormone replacement therapy (HRT) to mitigate cognitive risks, though more research is needed. The ISGE congress emphasized the importance of integrating brain health assessments into gynecological care for at-risk women.
