Two newly published studies suggest that humans may carry a genetic mechanism similar to that used by hibernating animals, which could potentially help reverse Type 2 diabetes. The research, published in the journal Cell Metabolism on May 12, 2026, identifies a gene called 'HIB1' that regulates metabolism during hibernation in bears and other mammals.
Scientists at the University of Cambridge found that a variant of this gene exists in humans and can be activated to improve insulin sensitivity. In experiments with mice, activating the human HIB1 gene reduced blood sugar levels by 30% over four weeks, without causing weight gain or other side effects.
Dr. Emily Carter, lead author of the study, stated: 'This is a promising step toward a new class of diabetes treatments that work with the body's natural metabolic processes.' The team plans to begin human clinical trials in early 2027.
Type 2 diabetes affects over 500 million people worldwide, according to the World Health Organization. Current treatments often focus on insulin regulation, but this approach targets the underlying metabolic dysfunction.
